Along with the roller bearing developed towards high speed and heavy load, the “tilting load effect” and bearing lubrication are in need of consideration in design of the bearing. The finite line contact isothermal elastohydrodynamic lubrication (EHL) numerical model of axially profiled tilted cylindrical roller under tilting load condition was established. The effects of tilting angle and entrainment velocity on subsurface von Mises stress were studied. The calculation results show that, the pressure distribution in the roller axial direction is uneven with tilting angle appeared. With the increase of tilting angle, the pressure and subsurface von Mises stress are increased at the load end. At constant loading of roller, the second pressure spike in exit restriction is increased significantly along with the increasing of the entrainment velocity, which causes the increase of maximum subsurface von Mises stress, and the location of the maximum subsurface von Mises stress is moved to surface layer. The study results show that the tilting angle of roller and entrainment velocity have a quite large influence on subsurface stress of the roller.