Lubrication experiments of strip in hot rolling were carried out under different lubrication conditions to analyze the effects of nano lubricants to parameters of rolling process，surface quality and thickness of the oxide layer.The experimental results show that the strips are rolled steadily in nano lubrication process, and rolling force is decreased by 10% 16.3% comparing with the lubrication conditions by traditional rolling fluid.The thickness of the final rolling is reduced by 10.8%.Nano lubrication can reduce the surface roughness of the strips, and improve their surface quality significantly.The thickness of oxide layer of the strip is just 7 μm when lubricated by nano lubricants, and the oxide layer is more uniformity and compact，which has less defect of cavity and crack.