Referenced the concept of compactibility,by associating the leakage rate and sealing force of the glove valve with soft seal,the calculation method of sealing force for glove valve with soft seal based on leakage rate was put forward.The gasket coefficient was determined by the leaking test and the method of data regression and then it was used to calculate the sealing force of the globe valve seals with different materials.The standard leaking test about Fluorinated Ethylenepropylene(Fs46) globe valve with soft seal was carried out,and the test results were compared with the calculating results.The results obtained by the proposed calculation method are consistent with the experimental results,which proves that the proposed method can accurately calculate the sealing force of the globe valve seals with different materials based on the target leakage rate.