Highspeed cutting TB6 titanium alloy test were conducted with coated carbide tools.It is established the empirical formula of cutting force under three situations of dry type,low temperature air,and normal temperature tiny mist though the multiple regression analysis and it is studied the parameters affect on cutting speed.The studies show that in the same parameter the maximum the dry type cutting force,the low temperature air in the middle,compared with the dry type,the cutting speed is reduced by 20% under the tiny mist lubricating.Adapt coated carbide tools to milling TB6 titanium alloy,it’s better to choose the tiny mist as the cooling lubricating medium,the cutting parameter should choose the high speed cutting speed and the radial cutting depth of and give the appropriate feeding speed and axial depth.