It is essential to study the predicting,detecting,preventing,evaluating,diagnosis capabilities and other techniques,in order to reduce the failure rate and potential hazard for the sealing systems.To develop advanced sealing materials and products to meet the requirement of harsh conditions,which is critical for the full lifecycle safety of key industries,major projects and equipment.Facing with the new challenges on the quality technology,safety,and lowemission industry,the integrity and reliability theory of rubber & plastic seals was studied.Taking an example on sealing integrity of the oil & gas industry,including the exploitation,transportation,and processing equipment,the intelligent and green method of design control techniques was analyzed.The research direction of sealing integrity and reliability is prospected.