When the hydrostatic spindle system work normally, the uneven temperature distribution of the system and the pressure distribution of the oil film can cause stress concentration and structure deformation of spindle system that might lead to the shaft premature failure . Based on the one-way FSI and FLUENT workbench co-simulation platform, the force-structure deformation,heat structure deformation and the stress distribution of the hydrostatic spindle were studied. The results show that the pressure in bearing static pressure cavity is distributed uniformly and the temperature gradient is large at the location of return chute and export and the average temperature is higher than that of the oil cushion when the hydrostatic spindle stops working. Oil film pressure and temperature distribution of the hydrostatic bearing have obvious effect on the radial deformation of the spindle and affect the spindle static stiffness. The rotor temperature rise of the electric spindle has no obvious effect on the radial deformation in the support position of the hydrostatic bearing but the main factor influencing the spindle stress distribution.