A scheme of intelligent centralized grease lubrication system using stepper motor valve as oil feeder was presented.The connection of main PLC and the configuration program of HMI were introduced,and the mechanical structure of stepper motor valve was illustrated.A scheme that more than one stepper motor is driven by only one driver was designed based on the technological requirements of centralized grease lubrication system and the control characteristic of stepper motor.The isolation circuit of the hardware was also researched.The actual application shows that the fault of the centralized grease lubrication system is reduced by using the stepper motor valve as the oil feeder.By using one driver to drive more than one stepper motor in intelligent grease lubrication system,the cost of the system is reduced, and the complexity of the system is decreased.