The twodimensional model of a packer rubber was established by the finite element analysis software,and under the axial load of 53.85 MPa,the influence of the four factors including the end face inclination,the subthickness of tube,the tube height and the friction coefficient of the the rubber tube on the maximum contact stress between the rubber tube and the casing at different levels was analyzed.The results show that the maximum contact stress is Wshaped distribution with the increasing of endface angle,it is increased first,then decreased,and finally tends to be stable with the increasing of subthickness,is decreased with the increasing of drum height,and is slowly decreased first and then increased sharply with the increasing of friction coefficient.When the end angle is 45 degrees,the thickness of rubber cylinder is 9 mm,the height of rubber cylinder is between 80 and 120 mm,and the friction coefficient is between 01 and 03,the maximum contact stress between the rubber tube and the casing of the packer studied is higher,and the sealing performance of rubber is better.Based on the results of finite element analysis,the response surface method experiment was designed to study the change of maximum contact pressure response of rubber under different levels of multifactors.It is found that the biggest factor influencing the response value of the maximum contact stress is friction coefficient,the smallest is tube height,and the interaction terms have significant effects on the response,including endface angle and tube height,endface angle and friction coefficient,subthickness of tube and friction coefficient,and tube height and friction coefficient.The optimum factor combination scheme of rubber tube sealing performance is that the endface angle is 482 degrees,the subthickness is 9 mm,the tube height is 90 mm,and the friction coefficient is 01.