In order to solve the failure problem of packer rubber in high temperature and high pressure well and improve its sealing performance,a kind of packer rubber material based on the nanofluidic system was proposed.The designed packer rubber material is supported by a kind of honeycomb skeleton inside which the mixture of a hydrophobic nanoporous medium and a kind of nonwetting liquid is encapsulated.The prepared sealing material can adjust its volume through the encapsulated liquid flow in and out of the nanochannels in the system to balance the external pressure change.Using ZSM-5 zeolitewater system as filling medium,the pressurevolume changing characteristics of the packer rubber material based on ZSM-5 zeolitewater system at different environmental temperature were obtained.Results show that when the environmental temperature changes in the range from 30 ℃ to 75 ℃,the upper pressure threshold pressure is increased and the lower threshold pressure is decreased with the ascension of temperature.The stress of service will stabilize in a more intercellular range and the effective deformation capacity will also increase with the lift of temperature.The unique sealing performance of the new packer rubber material can help to reducing the risk of sealing failure of the annulus between the tubing and the casing.