In order to study the effect of the interaction between nano-fillers with layered and spherical structures on the friction and wear behavior of polytetrafluoroethylene composites,nano-silica(nano-SiO2) and graphene oxide(GO) filled polytetrafluoroethylene（PTFE）composites were prepared by freeze-drying-ultrasonic blending-cold pressing-hot sintering method.The tribological properties of the nano-SiO2 and GO compound-modified PTFE composites were tested under dry friction conditions using the LSM-2R reciprocating friction and wear tester,and the transfer film morphology,elements distribution and three-dimensional morphology on the wear track were characterized by MicroXAM-800 non-contact three-dimensional surface profiler,scanning electron microscope(SEM) and energy spectrometer(EDS).The friction reduction mechanism of nano-SiO2 and GO was also revealed from the microscopic level.The results show that the friction and wear properties of PTFE composites can be improved by filling nano-SiO2 and GO separately,and GO is significantly better than nano-SiO2 in improving the wear resistance of PTFE at a low additive amount.There is a synergistic effect between GO and nano-SiO2 when composite filling,which further improves the tribological properties of the composite material compared to a single filling.Compared to pure PTFE,the wear rate of 3%nano-SiO2/0.5%GO/PTFE composite material is reduced by 60.36%.The mechanism analysis shows that the synergistic effect and the formation of uniform continuous transfer film are the main reasons for the excellent performance of nano-SiO2 and GO reinforced PTFE composites.