Aimed at the problems of quicker wear,high oil temperature,high leakage,less easy installation and shorter service life,the minimum diameter of the transmission passage and the number of the holes in the dynamic ring and the static ring were determined by the theoretical calculation of the transmission passage through the transmission seal.The optimal processing of the oil flow passage structure was carried out to make the two inclined holes of the movable ring be symmetrical and smooth,and make the inclined holes of the static ring be even through the end groove.The combination seal of polymer nylon 6 and fluoro rubber O-ring was put forward.The finite element analysis results show that the design size of the combined seal meets the requirements of sealing.The designed transmission seal was applied on the push feed centrifuge,it is shown that the product is stable in quality,reliable in operation and long in use,and can completely replace the imported transmission seal.