The nano-La2O3/nanoserpentine/PTFE matrix composite was prepared by uniform design method and using PTFE as matrix,modified nano Lanthanum Oxide and modified nano serpentine as additives.The experiment of tribology of the composite in fresh water environment was designed and carried out with a selfprepared water environment simulator.Origin software was used for curve fitting of the experimental data,SPSS software was used for multiple regression analysis to obtain the linear regression equation of tribological performance,and the theoretical optimal solution of friction coefficient and wear rate of the regression equation was solved through MATLAB.The tribological properties of the composite with the optimal ratio were compared and the wear surface morphology was analyzed.The results show that the experimental values of tribological properties of the composite are basically consistent with the theoretical results of regression analysis,the friction coefficient error is controlled within 5%,and the wear rate error is controlled within 10%.This result proves this method has feasibility to the prediction of the tribological properties of the PTFE matrix composite.