In order to study the effect of 3D printing anisotropy on frictional properties,polyether ether ketone (PEEK) specimens with three printing angles of 0°,45°,and 90° were prepared by fused deposition molding (FDM),and the effects of three different printing angles and load variations on the tribological properties and wear mechanisms of PEEK specimens were investigated.The MFT-5000 friction and wear tester was used to perform a reciprocal sliding friction test on PEEK material with water lubrication at room temperature,and the surface morphology after wear was observed with an ultra-deep field microscope.The results show that the friction coefficients of the three printing angle specimens under different loads are in descending order:0°specimen,90°specimen,and 45°specimen,and the wear rate is in descending order:90°specimen,45°specimen,and 0°specimen.As the load increases,the friction coefficients of the specimen with three different printing angles show a decreasing trend,and the wear rate shows an increasing trend.The wear mechanism of PEEK is surface layer peeling caused by adhesive wear and fatigue wear.