With the rapid development of the infrastructure construction in China, Tunnel Boring Machines(TBM) with Large Diameter are widely used. As the main key core parts of the TBM, the main drive seal has attracted much research attention and great progress has been made. This paper mainly focuses on the recent research of the main drive seal of TBM to collect and sort the research progress on seal material, seal structure, seal manufacture process, simulation bench and product application, and the future development is prospected in the end.