Aimed at the failure problem of hydrocyclone caused by erosion and abrasion of solid particles such as sediment in the drilling fluid during the oil drilling process,the erosion wear of hydrocyclone with non-Newtonian fluid as drilling fluid was studied by using CFD-DPM model.The effects of different flow rates,consistency coefficient,fluidity index,sand volume ratio and inlet inclination angle on the erosion wear of hydrocyclone inner wall were explored.The results show that the wear of the inner wall of the cyclone is in a spiral shape,the wear rate of the cone section increases with the decrease of the radius,and the underflow port is the most severely damaged part.When the flow velocity is from 5 m/s to 15 m/s and the sand volume ratio is from 1% to 9%,the maximum erosion rate of the hydrocyclone increases exponentially with the increase of the velocity,and the erosion area obviously expands.The sand volume ratio has a weaker effect on the maximum erosion rate at low flow velocity,while the maximum erosion rate is positively correlated with sand volume ratio at high flow velocity.The increase of the inlet inclination angle increases the downward axial velocity at the same time,so that the contact of the particles with the wall is reduced because the particles can reach the underflow port faster,and the erosion rate decreases linearly.The maximum erosion rate shows a gentle downward trend with the increase of the consistency coefficient,and decreases rapidly with the increase of the fluidity index.The influence of fluidity index on erosion damage is more severe than that of consistency coefficient.