Through the test of highspeed cutting TB6 titanium alloy,the surface integrity of titanium alloy,such as surface roughness,3D surface topography and surface microstructure were observed.The significance of effect on the surface roughness by cutting parameters was analyzed by using the range analysis,and the effect of lubrication cooling conditions on the surface topography and metamorphic layer was discussed.The results shown that the cutting parameters influencing the surface roughness can be sequenced in the order of radial cutting depth,cutting speed,feed rate,axial cutting depth.Compared with cold blast machining method,the machining method of minimal quantity lubrication can obtain lower surface roughness,and the machined surface structure of titanium alloy has no obvious grain deformation,indicating that the surface plastic deformation is the key factor affecting the machining surface roughness.