The friction pairs of Al2O3 ceramics and TC4 titanium alloy,316 stainless steel,2205 duplex stainless steel were chosen to be the study subjects for optimizing wear resistance materials of desalination highpressure pump.The friction and wear test of matching materials were carried out under three conditions of dry friction,pure water and seawater environmental media by using the vertical universal friction and wear testing machine.The friction coefficient and wear loss of the friction pairs were obtained quantitatively,and the surface topography of the specimen was analyzed.The influence law of load,speed and ambient medium on friction coefficient and wear loss was analyzed by using orthogonal experiment method.The results show that under the same conditions,the friction coefficient of TC4 titanium alloy and ceramic is smaller,and the wear loss of 2205 duplex stainless steel and ceramic is smaller.The environmental medium has a great influence on the friction coefficient,and the load has a great influence on the wear loss.In seawater environment,the wear scar of 2205 duplex stainless steel and 316 stainless steels are relatively shallow,and the wear mechanism is the interaction of fatigue wear,abrasive wear and corrosion wear.